Fast growing, slender, columnar.

Contains: mescaline, tyramine, 3-methoxytyramine, 3-4-dimethoxyphenethylamine.

Trichocereus bridgesii is easily recognizable for its formidable drooping 4-10 cm long spines. Like it's relatives, this species is a quick grower and is reported to grow up to 6m in height.

Description: It is a fast-growing columnar cactus , branching at the base that can grow 2–5 (-6) m tall with stems of up to 15–20 cm in diameter.

Stem: Upright light glaucous green coloured, , dark green in age.
Ribs: 4 to 8 ribs (usually 5-7), broad at base, obtuse, with a more or less deep horizontal depression above the areole
Spines: Honey-coloured to brown, located on the nodes in groups of up to 4. They can grow up to 6–7 8-(-10) cm in length and in fully grown plants are spaced evenly on the ribs, 2.5 to 3 cm apart.
Flowers: Very large, night blooming, fragrant, white up to 20 cm in diameter. Flowers tube and fruit covered with scales and black curled hairs.
Blooming time: Summer.