Leonotis leonurus has long been used in traditional African herbal medicine for fevers, headaches, dysentery, flu, chest infections, epilepsy, constipation, delayed menstruation, intestinal worms, spider bites, scorpion stings, hypertension and snakebites. Externally, it is often used for hemorrhoids, eczema, skin rashs and boils.
One experimental animal study suggests that "the aqueous leaf extract of Leonotis leonurus possesses antinociceptive, antiinflammatory, and hypoglycemic properties
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